Format

Send to

Choose Destination
J Epidemiol. 2017 Mar;27(3S):S92-S97. doi: 10.1016/j.je.2016.12.013. Epub 2017 Feb 3.

Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank Japan.

Author information

1
Department of Health Sciences, University of Yamanashi, Yamanashi, Japan. Electronic address: hyokomichi@yamanashi.ac.jp.
2
Department of Public Policy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
3
Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
4
Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
5
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan.
6
Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
7
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
8
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
9
RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
10
Department of Health Sciences, University of Yamanashi, Yamanashi, Japan.
11
Tokushukai Hospitals, Japan.
12
Nippon Medical School, Japan.
13
Juntendo University, Japan.
14
Nihon University, Japan.
15
Iwate Medical University, Japan.
16
Tokyo Metropolitan Institute of Gerontology, Japan.
17
The Cancer Institute Hospital of JFCR, Japan.
18
Aso Iizuka Hospital, Japan.
19
Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
20
Shiga University of Medical Science, Japan.
21
National Hospital Organization, Osaka National Hospital, Japan.
22
Fukujuji Hospital, Japan.

Abstract

BACKGROUND:

Evidence of characteristics of Japanese patients with diabetes from a large-scale population is necessary. Few studies have compared glycaemic controls, complications and comorbidities between type 1 and 2 diabetic patients. This paper focuses on illustrating a clinical picture of Japanese diabetic patients and comparing glycaemic control and prognoses between type 1 and 2 diabetes using multi-institutional data.

METHODS:

The BioBank Japan Project enrolled adult type 1 and 2 diabetic patients between fiscal years 2003 and 2007. We have presented characteristics, controls of serum glucose, cholesterol and blood pressure, prevalence of complications and comorbidities and survival curves. We have also shown glycaemic controls according to various individual profiles of diabetic patients.

RESULTS:

A total of 558 type 1 diabetic patients and 30,834 type 2 diabetic patients participated in this study. The mean glycated haemoglobin A1c was higher in type 1 diabetes than in type 2 diabetes. In the type 1 diabetic patients, the glycated haemoglobin A1c had no consistent trend according to age and body mass index. The Kaplan-Meier estimates represented a longer survival time from baseline with type 1 diabetes than with type 2 diabetes. Compared with type 1 diabetic patients, type 2 diabetic patients had double the prevalence of macrovascular complications.

CONCLUSIONS:

This work has revealed detailed plasma glucose levels of type 1 and 2 diabetic patients according to age, body mass index, blood pressure, serum cholesterol levels and smoking and drinking habits. Our data have also shown that the prognosis is worse for type 2 diabetes than for type 1 diabetes in Japan.

KEYWORDS:

Comorbidity; Diabetes; Glycated haemoglobin A1c; Kaplan–Meier estimate; Smoking

PMID:
28162891
PMCID:
PMC5350587
DOI:
10.1016/j.je.2016.12.013
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center