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Asia Pac J Ophthalmol (Phila). 2017 Jan-Feb;6(1):40-44. doi: 10.22608/APO.2015197.

Optimal Duration for the Use of 0.5% LevofloxacinEye Drops Before Vitreoretinal Surgery.

Author information

  • 1Peking university People's Hospital, Beijing.
  • 2Yat-sen Ophthalmic Center of Sun Yat-Sen University, Guangzhou.
  • 3Xiangya second Hospital of Central South University, Changsha.
  • 4Sichuan University Huaxi Hospital, Chengdu.
  • 5Eye Hospital of Wenzhou Medical University, Wenzhou.
  • 6Second Hospital of Jilin University EyeHospital, Changchun.
  • 7Eye Center of Tianjin Medical University, Tianjin, China.



To investigate various regimens of prophylactic antibiotic therapy for vitreoretinal surgery.


This study compared different prophylactic therapies with 0.5% levofloxacin eye drops.


Two hundred nine patients from 7 hospitals scheduled to undergo vitreoretinal surgery were randomized into 3 groups to receive 0.5% levofloxacin eye drops for 1 day (6 times/d), 2 days (3 times/d), or 3 days (3 times/d) before surgery (groups 1D, 2D, and 3D, respectively). all patients received 3 applications of levofloxacin eye drops at 15-minute intervals beginning 1 hour before surgery and conjunctival sac disinfection with 5.0% povidone-iodine 15 minutes before surgery. conjunctival swabs were cultured before levofloxacin therapy (T0), on the morning of surgery (T1), after povidone-iodine disinfection (T2), immediately after surgery (T3), 1 day postoperatively (T4), and 1 week postoperatively (T5).


the positive bacterial culture rates in groups 1D, 2D, and 3D fell, respectively, from 37.33%, 30.77%, and 31.88% at t0 to 10.67%, 12.31%, and 11.59% at t1 and 1.33%, 0%, and 0% at T2. at each time point (T0-T5), there were no significant differences among the groups in positive bacterial culture rate. the bacterial eradication rates in groups 1D, 2D, and 3D were, respectively, 100%, 94.74%, and 90.00% at T1 (after levofloxacin) and 100% in all groups at T2 (after povidone-iodine).


The efficacy of levofloxacin in preventing postoperative infection was similar in the 3 treatment groups. it is recommended that 0.5% levofloxacin be used for only 1 day before vitreoretinal sur-gery (6 times/d) to minimize the use of prophylactic antibiotics.


antibiotic; central retinal artery occlusion; levofloxacin; prophylaxis; vitreoretinal surgery

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