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Amino Acids. 2017 May;49(5):871-886. doi: 10.1007/s00726-017-2383-8. Epub 2017 Feb 4.

Behavioral and inflammatory response in animals exposed to a low-pressure blast wave and supplemented with β-alanine.

Author information

1
Institute of Exercise Physiology and Wellness, Sport and Exercise Science, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32816, USA. jay.hoffman@ucf.edu.
2
Division of Psychiatry, Anxiety and Stress Research Unit, Faculty of Health Sciences, Beer-Sheva Mental Health Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
3
Department of Mechanical Engineering, Ben-Gurion University, Beer-Sheva, Israel.
4
Institute of Exercise Physiology and Wellness, Sport and Exercise Science, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32816, USA.
5
Israel Defense Forces, Medical Corps, Tel Aviv, Israel.

Abstract

This study investigated the benefit of β-alanine (BA) supplementation on behavioral and cognitive responses relating to mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) in rats exposed to a low-pressure blast wave. Animals were fed a normal diet with or without (PL) BA supplementation (100 mg kg-1) for 30-day, prior to being exposed to a low-pressure blast wave. A third group of animals served as a control (CTL). These animals were fed a normal diet, but were not exposed to the blast. Validated cognitive-behavioral paradigms were used to assess both mTBI and PTSD-like behavior on days 7-14 following the blast. Brain-derived neurotrophic factor (BDNF), neuropeptide Y, glial fibrillary acidic protein (GFAP) and tau protein expressions were analyzed a day later. In addition, brain carnosine and histidine content was assessed as well. The prevalence of animals exhibiting mTBI-like behavior was significantly lower (p = 0.044) in BA than PL (26.5 and 46%, respectively), but no difference (p = 0.930) was noted in PTSD-like behavior between the groups (10.2 and 12.0%, respectively). Carnosine content in the cerebral cortex was higher (p = 0.048) for BA compared to PL, while a trend towards a difference was seen in the hippocampus (p = 0.058) and amygdala (p = 0.061). BDNF expression in the CA1 subregion of PL was lower than BA (p = 0.009) and CTL (p < 0.001), while GFAP expression in CA1 (p = 0.003) and CA3 (p = 0.040) subregions were higher in PL than other groups. Results indicated that BA supplementation for 30-day increased resiliency to mTBI in animals exposed to a low-pressure blast wave.

KEYWORDS:

BDNF; Carnosine; GFAP; Mild traumatic brain injury; Supplementation

PMID:
28161798
PMCID:
PMC5383715
DOI:
10.1007/s00726-017-2383-8
[Indexed for MEDLINE]
Free PMC Article

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