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Allergol Immunopathol (Madr). 2017 Jul - Aug;45(4):356-361. doi: 10.1016/j.aller.2016.10.006. Epub 2017 Feb 1.

Bacillus Calmette-Guérin vaccine complications in Iranian children at a University Hospital.

Author information

1
Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
2
Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: lotfianferial@yahoo.com.
3
Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

Abstract

BACKGROUND:

Although the BCG vaccine remains the only available vaccine, a number of complications from local to systemic adverse reactions can occur.

OBJECTIVE:

The aim of the study was to review the clinical features and treatment of Bacillus Calmette-Guérin (BCG) complications in children.

METHODS:

Children with clinical and laboratory findings compatible with a diagnosis of local complication and disseminated disease at Masih Daneshvari Medical Center were enrolled from March 2013 to September 2015.

RESULTS:

Among 49 children with BCG complications, 35 (71%) had local complications and 14 (29%) had disseminated disease. The mean age at presentation was nine months (range: 1m-13y). The male to female ratio was 1.7:1. Suppurative lymphadenitis was seen in 25 of 35 (71%) cases. Among cases with disseminated disease, primary immunodeficiency (PID) was identified in nine (64%) cases. All cases with non-suppurative lymphadenitis were managed conservatively. Twenty (80%) cases with suppurative lymphadenitis were managed differently with medical treatment or surgery. In disseminated cases, three (43%) were treated with only medical treatment and eight (57%) with both medical and surgical treatment.

CONCLUSIONS:

Most children with BCG complications had a local disease in our study. A higher rate of disseminated disease was also observed. In addition, PID was identified in most children with disseminated disease. Development of more appropriate BCG vaccines and changing the current vaccination programme in cases with suspected PID are required in our country.

KEYWORDS:

Bacillus Calmette–Guerin; Complications; Disseminated; Lymphadenitis

PMID:
28161281
DOI:
10.1016/j.aller.2016.10.006
[Indexed for MEDLINE]

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