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BMC Pregnancy Childbirth. 2017 Feb 3;17(1):53. doi: 10.1186/s12884-017-1236-5.

Pregnancy in fanconi anaemia with bone marrow failure: a case report and review of the literature.

Author information

1
Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy. flasorbi@gmail.com.
2
Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy.
3
Department of Health Sciences - Division of Anaesthesiology, University of Florence, Careggi University Hospital, Florence, Italy.

Abstract

BACKGROUND:

Fanconi anaemia is a rare inherited disease characterized by congenital abnormalities, progressive bone marrow failure and predisposition to malignancy. Successful pregnancies in transplanted patients have been reported. In this paper we will describe the pregnancy of a patient with Fanconi anaemia without transplantation.

CASE PRESENTATION:

A 34-year-old nulliparous woman with Fanconi anaemia was referred to our institution. Pregnancy was complicated by progressive pancytopenia and two severe infections. C-section was performed at 36 weeks. Both infant and mother are well.

CONCLUSION:

Successful pregnancy in a Fanconi anaemia patient with bone marrow failure is possible. The mode of delivery in patients with bone marrow failure should be determined by obstetric indications. The case highlights the safe outcome of the pregnancy with strict clinical and laboratory control by a multidisciplinary team.

KEYWORDS:

Antenatal care; Fanconi Anaemia; High-risk pregnancy

PMID:
28158987
PMCID:
PMC5291952
DOI:
10.1186/s12884-017-1236-5
[Indexed for MEDLINE]
Free PMC Article

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