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Mol Cell. 2017 Feb 2;65(3):375-377. doi: 10.1016/j.molcel.2017.01.018.

When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position.

Author information

1
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
2
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address: arb@stowers.org.

Abstract

In this issue, Aeschimann et al. (2017) demonstrate that, depending on the target location site (5'UTR or 3'UTR), LIN41 triggers repression of translation or mRNA decay, suggesting that one factor may use two independent pathways of post-transcriptional gene regulation.

KEYWORDS:

RNA-binding protein; early development; gene regulation; mRNA decay; translation repression

PMID:
28157501
DOI:
10.1016/j.molcel.2017.01.018
[Indexed for MEDLINE]
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