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Genomics Inform. 2016 Dec;14(4):234-240. doi: 10.5808/GI.2016.14.4.234. Epub 2016 Dec 31.

Tissue Specific Expression Levels of Apoptosis Involved Genes Have Correlations with Codon and Amino Acid Usage.

Author information

1
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz 61357-83151, Iran.
2
Department of Molecular Genetics, Faculty of Biosciences, Tarbiat Modares University of Tehran, Tehran 14115116, Iran.
3
Department of Medical Genetics, Nika Center of Preventive Medicine and Health Promotion, Tehran 1418944711, Iran.
4
Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran.

Abstract

Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively expressed in human tissues. We found some correlations between codon/amino acid usage and tissue specific expression level of genes. The findings can be significant for understanding the translational selection on these features. The selection may play an important role in the differentiation of human tissues and can be considered for future studies in diagnosis of some diseases such as cancer.

KEYWORDS:

apoptosis; codon; gene expression regulation; translation

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