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Biochem Biophys Res Commun. 2017 Mar 11;484(3):612-617. doi: 10.1016/j.bbrc.2017.01.149. Epub 2017 Jan 30.

C21orf57 is a human homologue of bacterial YbeY proteins.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
2
Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
3
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: gwalker@mit.edu.

Abstract

The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its bacterial and chloroplast counterparts, the HuYbeY protein is an RNase and that it retains sufficient function in common with bacterial YbeY proteins to partially suppress numerous aspects of the complex phenotype of an Escherichia coli ΔybeY mutant. Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, results in a severe growth phenotype. This observation suggests that the function of HuYbeY in human cells is likely regulated through specific interactions with partner proteins similarly to the way YbeY is regulated in bacteria.

KEYWORDS:

C21orf57; RNase; YBEY; Yeast

PMID:
28153719
PMCID:
PMC5318257
DOI:
10.1016/j.bbrc.2017.01.149
[Indexed for MEDLINE]
Free PMC Article

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