A supramolecular material for dual-modal imaging and targeted cancer therapy

Talanta. 2017 Apr 1:165:297-303. doi: 10.1016/j.talanta.2016.12.068. Epub 2016 Dec 25.

Abstract

Recently, how to design a formulation system with simultaneous diagnosis and therapy toward cancer has attracted tremendous attention. Herein, a supramolecular material was prepared via a facile method by the co-intercalation of folic acid (FA) and doxorubicin (DOX) into the gallery of Gd3+-doped layered double hydroxides (LDHs), followed by surface adsorption of fluorescein isothiocyanate (FITC). This supramolecular agent was proved to exhibit excellent magnetic resonance imaging (MRI) and fluorescence imaging (FI) behavior, as well as chemotherapy toward cancer (KB cell). The co-intercalated FA enables an efficient and selective drug delivery with good specificity. This work provides a facile approach for the fabrication of a drug formulation with dual-modal imaging and targeted therapy, which could be potentially used in the practical chemotherapy and medical imaging.

Keywords: Chemotherapy; Dual-modal imaging; Supramolecular.

MeSH terms

  • Carcinoma, Squamous Cell / diagnostic imaging*
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / therapy
  • Cell Survival / drug effects
  • Dextrans
  • Doxorubicin / pharmacology*
  • Fluorescein-5-isothiocyanate / analogs & derivatives
  • Folic Acid / chemistry*
  • Gadolinium / chemistry*
  • Humans
  • Hydroxides / chemistry*
  • Intercalating Agents / chemistry
  • Magnetic Resonance Imaging / methods*
  • Optical Imaging / methods*
  • Tumor Cells, Cultured

Substances

  • Dextrans
  • Hydroxides
  • Intercalating Agents
  • fluorescein isothiocyanate dextran
  • Doxorubicin
  • Folic Acid
  • Gadolinium
  • Fluorescein-5-isothiocyanate