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Nat Prod Res. 2017 Nov;31(22):2669-2674. doi: 10.1080/14786419.2017.1283494. Epub 2017 Feb 2.

Phytochemical and pharmacological variability in Golden Thistle functional parts: comparative study of roots, stems, leaves and flowers.

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a Faculté de Médicine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie , Mohammed V University in Rabat , Rabat , Morocco.
b Laboratoire de Contrôle de Qualité de Médicament, Division de Médicament et Pharmacie, Ministère de santé , Service de Physicochimie , Rabat , Morocco.
c Faculté des Sciences Kénitra , Université Ibn Tofail , Rabat , Morocco.
d Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Pharmaceutical and Toxicological Analysis Research Team , Mohammed V University in Rabat , Rabat , Morocco.
e Department of Analytical Chemistry and Pharmaceutical Technology, CePhaR , Vrije Universiteit Brussel (VUB) , Brussels , Belgium.
f Biochemistry Department , Military Hospital Mohammed V , Rabat , Morocco.


Scolymus hispanicus or the Golden Thistle, locally known as 'Guernina' or 'Taghediwt', is one of the most appreciated wild vegetables in Morocco. This study aims to characterise the functional chemical and pharmacological variability of Scolymus hispanicus parts (roots, stems, leaves and flowers). The chemical analysis revealed higher content of α-tocopherol in the flowers (2.79 ± 0.07 mg/100 g) and lead to the identification of 3 flavonoids and 13 phenolic acids, with high content of gallic acid in leaves (187.01 ± 10.19 mg/kg); chlorogenic (936.18 ± 92.66 mg/kg) and caffeic (4400.14 ± 191.43 mg/kg) acids in flowers, roots were much more higher in sinapic acid (0.25 ± 0.03 mg/kg) compared to the other parts. Moreover, Scolymus hispanicus ethanolic extracts exhibited interesting antioxidant and antimicrobial properties, promising anti-amylase and anti-glucosidase activities and relevant diuretic effect that confirms its traditional uses.


Scolymus hispanicus; antidiabetic; antimicrobial; antioxidant; diuretic; phenolic

[Indexed for MEDLINE]

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