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Int J Cancer. 2017 May 1;140(9):2023-2031. doi: 10.1002/ijc.30630. Epub 2017 Feb 14.

Niacin intake and risk of skin cancer in US women and men.

Park SM1,2,3, Li T1, Wu S4,5, Li WQ4,6, Weinstock M4,6,7,8, Qureshi AA1,4,6,8, Cho E1,4,6.

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Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Department of Dermatology, The Warren Alpert Medical School, Brown University, Providence, RI.
Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China.
Department of Epidemiology, Brown University School of Public Health, Providence, RI.
Department of Veterans Affairs Medical Center, Center for Dermatoepidemiology, Providence, RI.
Department of Dermatology, Rhode Island Hospital, Providence, RI.


A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospectively evaluated whether total, dietary and supplemental niacin intake was associated with skin cancer risk based on 72,308 women in the Nurses' Health Study (1984-2010) and 41,808 men in the Health Professionals Follow-up Study (1986-2010). Niacin intake was assessed every 2 to 4 years during follow-up and cumulative averaged intake. Cox proportional hazard models were used to compute the hazard ratios (HR) and 95% confidence intervals (CI) and cohort-specific results were pooled using a random-effects model. During the follow-up, we documented 23,256 BCC, 2,530 SCC and 887 melanoma cases. Total niacin intake was inversely associated with SCC risk; the pooled HR for top vs. bottom quintiles was 0.84 (95% CI = 0.74-0.95; ptrend  = 0.08). However, there were a marginally positive association between total niacin intake and BCC risk; the pooled HR for top versus bottom quintiles was 1.05 (95% CI = 1.01-1.10; ptrend  < 0.01). Higher total niacin intake was also marginally positively associated with melanoma risk in men, but not in women. The results were similar in stratified analyses according to sun exposure related factors and by body location of melanoma and SCC. Our study supports a potential beneficial role of niacin intake in relation to SCC but not of BCC or melanoma.


basal cell carcinoma; melanoma; niacin intake; skin cancer; squamous cell carcinoma

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