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Mol Cells. 2017 Jan;40(1):1-9. doi: 10.14348/molcells.2017.2319. Epub 2017 Jan 26.

SR Proteins: Binders, Regulators, and Connectors of RNA.

Author information

1
Department of Bioconvergent Science and Technology, Dankook University, Yongin 16890, Korea.

Abstract

Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm.

KEYWORDS:

RNA-binding proteins; SR proteins; export; splicing; transcription; translation

PMID:
28152302
PMCID:
PMC5303883
DOI:
10.14348/molcells.2017.2319
[Indexed for MEDLINE]
Free PMC Article

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