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J Magn Reson Imaging. 2017 Jul;46(1):218-227. doi: 10.1002/jmri.25575. Epub 2017 Feb 2.

3D myocardial T1 mapping using saturation recovery.

Author information

1
Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.
2
Philips Health Systems, London, UK.
3
Wellcome Trust and EPSRC Medical Engineering Center, King's College London, UK.
4
BHF Centre of Excellence, King's College London, UK.
5
NIHR Biomedical Research Centre, King's College London.
6
Pontificia Universidad Católica de Chile, Escuela de Ingeniería, Santiago, Chile.

Abstract

PURPOSE:

To propose a 3D quantitative high-resolution T1 mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1 phantom and in healthy subjects.

MATERIALS AND METHODS:

The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8 mm3 . For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T1 phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols.

RESULTS:

There was good agreement between the T1 values measured in a T1 phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6 ± 31 msec vs. 1123.6 ± 8 msec, P = 0.9947). Mean and standard deviation of the myocardial T1 values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881 ± 40 msec, 1181.3 ± 32 msec, and 1153.6 ± 28 msec respectively.

CONCLUSION:

The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T1 -mapping with T1 values in good agreement with the 2D SASHA and improved precision.

LEVEL OF EVIDENCE:

2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:218-227.

KEYWORDS:

MRI; T1 mapping; accuracy; precision; saturation-recovery

PMID:
28152227
PMCID:
PMC5518207
DOI:
10.1002/jmri.25575
[Indexed for MEDLINE]
Free PMC Article

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