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Steroids. 1989 Jul;54(1):71-99.

Novel steroidal pure antiestrogens.

Author information

1
Research Department 1, ICI Pharmaceuticals, Macclesfield, Cheshire, UK.

Abstract

A series of steroidal estrogen antagonists with no intrinsic estrogenicity in rat uterotrophic-antiuterotrophic tests has been discovered. The compounds are derivatives of estradiol containing amidoalkyl side chains at the 7 alpha-position. The most potent compounds are N-n-butyl-N-methyl-11-(3,17 beta-dihydroxyestra- 1,3,5(10)-trien-7 alpha-yl) undecanamide and N-2,2,3,3,4,4,4-heptafluorobutyl-N-methyl-11-(3,17 beta-dihydroxyestra- 1,3,5(10)-trien-7 alpha-yl) undecanamide. Structure activity relationships are discussed.

PMID:
2815158
DOI:
10.1016/0039-128x(89)90076-7
[Indexed for MEDLINE]

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