Format

Send to

Choose Destination
Ann Saudi Med. 2017 Jan-Feb;37(1):64-71. doi: 10.5144/0256-4947.2017.64.

Effect of Nigella sativa supplementation on lung function and inflammatory mediatorsin partly controlled asthma: a randomized controlled trial.

Author information

1
Dr. Abdullah Bamosa, Department of Physiology,, College of Medicine, University of Dammam,, PO Box 2114, Dammam 31451,, Saudi Arabia, T: +966-505853161,, +966-543440929, bamosa@uod.edu.sa,, absheikh@uod.edu.sa, ORCID: http://orcid.org/0000.0003-3061-6626.

Abstract

BACKGROUND:

Nigella sativa and its derivatives have been reported to have anti-inflammatory and bronchodilator effects, but the effects have been evaluated in only a few clinical studies.

OBJECTIVES:

To determine the effect of N sativa supplementation on inflammation of the airways and limitation of airflow in partly controlled asthma patients.

DESIGN:

Single-blind, placebo-controlled, randomized study.

SETTING:

Asthma and allergy clinic of a university hospital in eastern Saudi Arabia.

PATIENTS AND METHODS:

Patients were divided into three groups. A control group (n=24) received the placebo, while NS-1 and NS-2 groups (n=26 each) received 1 and 2 g/day of N sativa, respectively, for 3 months along with maintenance inhaled therapy.

MAIN OUTCOME MEASURE(S):

Asthma control test (ACT) score, fractional exhaled nitric oxide (FeNO), peak expiratory flow (PEF) variability and other pulmonary function tests, IgE, serum cytokines, and frequency of exacerbations.

RESULTS:

FEF25-75% and FEV1 (% predicted) increased significantly (P < .05) at both 6 and 12 weeks in the NS-2 group. PEF variability significantly improved in both NS-1 and NS-2 groups at 6 and 12 weeks as compared with the controls (P < .05). FeNO and serum IgE decreased significantly after 12 weeks in both the NS-1 and NS-2 groups vs baseline (P < .05). Both doses of N sativa produced a significant increase in the serum IFN-gamma at 12 weeks vs baseline (P < .05) as well as a significant improvement in the ACT score at 6 and 12 weeks vs baseline (P < .001, < .01). Significantly fewer patients had exacerbations in the NS-1 group (P < .05).

CONCLUSION:

N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.

LIMITATIONS:

No bronchoalveolar lavage or sputum samples taken for measurement of asthma markers. ISRCTN registry: ISRCTN48853858 DOI 10.1186/ISRCTN48853858.

PMID:
28151459
PMCID:
PMC6148976
DOI:
10.5144/0256-4947.2017.64
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center