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J Neurosci Res. 2017 Aug;95(8):1528-1539. doi: 10.1002/jnr.24003. Epub 2017 Feb 2.

Roles of palmitoylation in axon growth, degeneration and regeneration.

Author information

1
Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair).
2
Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140.

Abstract

The protein-lipid modification palmitoylation plays important roles in neurons, but most attention has focused on roles of this modification in the regulation of mature pre- and post-synapses. However, exciting recent findings suggest that palmitoylation is also critical for both the growth and integrity of neuronal axons and plays previously unappreciated roles in conveying axonal anterograde and retrograde signals. Here we review these emerging roles for palmitoylation in the regulation of axons in health and disease.

KEYWORDS:

Axon degeneration; DLK; Peripheral Neuropathy; Protein trafficking; Retrograde Transport; Wallerian

PMID:
28150429
PMCID:
PMC5471117
DOI:
10.1002/jnr.24003
[Indexed for MEDLINE]
Free PMC Article

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