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Transfusion. 2017 Jun;57(6):1347-1358. doi: 10.1111/trf.14006. Epub 2017 Feb 2.

Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.

Author information

1
School of Medicine and Pharmacology, The University of Western Australia.
2
Department of Haematology, Royal Perth Hospital.
3
PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.
4
Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland.
5
School of Surgery, University of Western Australia.
6
Centre for Population Health Research, Curtin University, Perth, Western Australia, Australia.
7
Service 4, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
8
Business Intelligence Unit, South Metropolitan Health Service.
9
School of Surgery, Faculty of Medicine Dentistry and Health Sciences, The University of Western Australia.
10
Clinical Training and Evaluation Centre (CTEC), University of Western Australia, Perth, Western Australia, Australia.
11
Department of Health, Western Australia, Australia.
12
Accumen LLC, San Diego, California.
13
School of Paediatrics and Child Health and School of Primary and Aboriginal and Rural Health, The University of Western Australia, Perth, Western Australia, Australia.
14
Centre for Population Health Research, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.

Abstract

BACKGROUND:

Patient blood management (PBM) programs are associated with improved patient outcomes, reduced transfusions and costs. In 2008, the Western Australia Department of Health initiated a comprehensive health-system-wide PBM program. This study assesses program outcomes.

STUDY DESIGN AND METHODS:

This was a retrospective study of 605,046 patients admitted to four major adult tertiary-care hospitals between July 2008 and June 2014. Outcome measures were red blood cell (RBC), fresh-frozen plasma (FFP), and platelet units transfused; single-unit RBC transfusions; pretransfusion hemoglobin levels; elective surgery patients anemic at admission; product and activity-based costs of transfusion; in-hospital mortality; length of stay; 28-day all-cause emergency readmissions; and hospital-acquired complications.

RESULTS:

Comparing final year with baseline, units of RBCs, FFP, and platelets transfused per admission decreased 41% (p < 0.001), representing a saving of AU$18,507,092 (US$18,078,258) and between AU$80 million and AU$100 million (US$78 million and US$97 million) estimated activity-based savings. Mean pretransfusion hemoglobin levels decreased 7.9 g/dL to 7.3 g/dL (p < 0.001), and anemic elective surgery admissions decreased 20.8% to 14.4% (p = 0.001). Single-unit RBC transfusions increased from 33.3% to 63.7% (p < 0.001). There were risk-adjusted reductions in hospital mortality (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.67-0.77; p < 0.001), length of stay (incidence rate ratio, 0.85; 95% CI, 0.84-0.87; p < 0.001), hospital-acquired infections (OR, 0.79; 95% CI, 0.73-0.86; p < 0.001), and acute myocardial infarction-stroke (OR, 0.69; 95% CI, 0.58-0.82; p < 0.001). All-cause emergency readmissions increased (OR, 1.06; 95% CI, 1.02-1.10; p = 0.001).

CONCLUSION:

Implementation of a unique, jurisdiction-wide PBM program was associated with improved patient outcomes, reduced blood product utilization, and product-related cost savings.

Comment in

PMID:
28150313
DOI:
10.1111/trf.14006
[Indexed for MEDLINE]

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