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Prev Med Rep. 2017 Jan 26;5:285-288. doi: 10.1016/j.pmedr.2017.01.013. eCollection 2017 Mar.

Associations of objectively measured moderate-to-vigorous-intensity physical activity and sedentary time with all-cause mortality in a population of adults at high risk of type 2 diabetes mellitus.

Author information

1
Department of Health Sciences, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care - East Midlands (CLAHRC - EM), Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
2
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
3
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; Leicester Diabetes Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care - East Midlands (CLAHRC - EM), Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom.
4
Charles Perkins Center, Prevention Research Collaboration, School of Public Health, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia; Department of Epidemiology and Public Health, Institute of Epidemiology and Healthcare, University College London, London, WC1E 6BT, United Kingdom.
5
National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Diabetes Research Centre, Leicester General Hospital, Leicester, Leicestershire, LE5 4PW, United Kingdom; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, United Kingdom.

Abstract

The relationships of physical activity and sedentary time with all-cause mortality in those at high risk of type 2 diabetes mellitus (T2DM) are unexplored. To address this gap in knowledge, we examined the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with all-cause mortality in a population of adults at high risk of T2DM. In 2010-2011, 712 adults (Leicestershire, U.K.), identified as being at high risk of T2DM, consented to be followed up for mortality. MVPA and sedentary time were assessed by accelerometer; those with valid data (≥ 10 hours of wear-time/day with ≥ 4 days of data) were included. Cox proportional hazards regression models, adjusted for potential confounders, were used to investigate the independent associations of MVPA and sedentary time with all-cause mortality. 683 participants (250 females (36.6%)) were included and during a mean follow-up period of 5.7 years, 26 deaths were registered. Every 10% increase in MVPA time/day was associated with a 5% lower risk of all-cause mortality [Hazard Ratio (HR): 0.95 (95% Confidence Interval (95% CI): 0.91, 0.98); p = 0.004]; indicating that for the average adult in this cohort undertaking approximately 27.5 minutes of MVPA/day, this benefit would be associated with only 2.75 additional minutes of MVPA/day. Conversely, sedentary time showed no association with all-cause mortality [HR (every 10-minute increase in sedentary time/day): 0.99 (95% CI: 0.95, 1.03); p = 0.589]. These data support the importance of MVPA in adults at high risk of T2DM. The association between sedentary time and mortality in this population needs further investigation.

KEYWORDS:

Cox proportional hazards regression; Moderate-to-vigorous-intensity physical activity; Mortality; Physical activity; Sedentary; Type 2 diabetes mellitus

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