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Mol Cancer. 2017 Jan 31;16(1):25. doi: 10.1186/s12943-017-0598-7.

Circular RNAs in human cancer.

Wang Y1,2,3, Mo Y1,2,3, Gong Z2,4, Yang X1, Yang M1, Zhang S1, Xiong F1, Xiang B1,2,3, Zhou M2,3,5, Liao Q2,5, Zhang W2, Li X2,3, Li X1,2,3, Li Y2,6, Li G1,2,3, Zeng Z7,8,9, Xiong W10,11,12.

Author information

1
Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.
2
Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China.
3
Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
4
Department of Stomatolog, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
5
Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
6
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
7
Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China. zengzhaoyang@csu.edu.cn.
8
Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China. zengzhaoyang@csu.edu.cn.
9
Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. zengzhaoyang@csu.edu.cn.
10
Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China. xiongwei@csu.edu.cn.
11
Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China. xiongwei@csu.edu.cn.
12
Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. xiongwei@csu.edu.cn.

Abstract

CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique structure, they are more stable than linear RNAs. CircRNAs play important roles in the carcinogenesis of cancer. The expression of circRNAs is correlated with patients' clinical characteristics, and circRNAs play a vital role in many aspects of malignant phenotypes, including cell cycle, apoptosis, vascularization, and invasion; metastasis as a RNA sponge, binding to RBP; or translation. Therefore, it is meaningful to further study the mechanism of interactions between circRNAs and tumors. The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.

KEYWORDS:

Biomarker; Cancer; Circular RNAs; Regulation; Splicing

PMID:
28143578
PMCID:
PMC5282898
DOI:
10.1186/s12943-017-0598-7
[Indexed for MEDLINE]
Free PMC Article

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