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J Epidemiol. 2017 Apr;27(4):152-162. doi: 10.1016/j.je.2016.05.004. Epub 2017 Jan 5.

Fruit and vegetable intake and the risk of overall cancer in Japanese: A pooled analysis of population-based cohort studies.

Author information

1
Department of Food Science and Nutrition, Nara Women's University Guraduate School of of Humanities and Sciences, Nara, Japan.
2
AXA Department of Health and Human Security, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: mnminoue@m.u-tokyo.ac.jp.
3
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
4
Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
5
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
6
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
7
Department of Preventive Medicine, Saga Medical School, Faculty of Medicine, Saga University, Saga, Japan.
8
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
9
Department of Epidemiology and International Health, International Clinical Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
10
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
11
Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
12
Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.

Abstract

BACKGROUND:

A series of recent reports from large-scale cohort studies involving more than 100,000 subjects reported no or only very small inverse associations between fruit and vegetable intake and overall cancer incidence, despite having sufficient power to do so. To date, however, no such data have been reported for Asian populations.

OBJECTIVE:

To provide some indication of the net impact of fruit and vegetable consumption on overall cancer prevention, we examined these associations in a pooled analysis of large-scale cohort studies in Japanese populations.

METHODS:

We analyzed original data from four cohort studies that measured fruit and vegetable consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model.

RESULTS:

During 2,318,927 person-years of follow-up for a total of 191,519 subjects, 17,681 cases of overall cancers were identified. Consumption of fruit or vegetables was not associated with decreased risk of overall cancers: corresponding HRs for the highest versus lowest quartiles of intake for men and women were 1.03 (95% CI, 0.97-1.10; trend p = 1.00) and 1.03 (95% CI, 0.95-1.11; trend p = 0.97), respectively, for fruit and 1.07 (95% CI, 1.01-1.14; trend p = 0.18) and 0.98 (95% CI, 0.91-1.06; trend p = 0.99), respectively, for vegetables, even in analyses stratified by smoking status and alcohol drinking.

CONCLUSIONS:

The results of this pooled analysis do not support inverse associations of fruit and vegetable consumption with overall cancers in the Japanese population.

KEYWORDS:

Cancer risk; Fruit and vegetable intake; Japanese; Pooled analysis

PMID:
28142032
PMCID:
PMC5376310
DOI:
10.1016/j.je.2016.05.004
[Indexed for MEDLINE]
Free PMC Article

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