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PLoS One. 2017 Jan 31;12(1):e0171148. doi: 10.1371/journal.pone.0171148. eCollection 2017.

Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques.

Author information

1
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, United States of America.
2
California National Primate Research Center, University of California, Davis, California, United States of America.
3
Department of Psychology, University of California, Davis, California, United States of America.
4
Hologic, San Diego, California, United States of America.
5
Blood Systems Research Institute and University of California, San Francisco, California, United States of America.

Abstract

Animal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. Humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. We inoculated 2 non-pregnant rhesus macaques with a 2015 Brazilian ZIKV strain. Consistent with most human infections, the animals experienced no clinical disease but developed short-lived plasma viremias that cleared as neutralizing antibody developed. In 1 animal, viral RNA (vRNA) could be detected longer in whole blood than in plasma. Despite no major histopathologic changes, many adult tissues contained vRNA 14 days post-infection with highest levels in hemolymphatic tissues. These observations warrant further studies to investigate ZIKV persistence and its potential clinical implications for transmission via blood products or tissue and organ transplants.

PMID:
28141843
PMCID:
PMC5283740
DOI:
10.1371/journal.pone.0171148
[Indexed for MEDLINE]
Free PMC Article

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