Surgically Induced Necrotizing Scleritis Following Strabismus Surgery Treated Successfully with Topical N-acetylcysteine in a Child with Congenital Fibrosis of Extraocular Muscles and Varadi Papp Syndrome

Strabismus. 2017 Mar;25(1):39-42. doi: 10.1080/09273972.2016.1277768. Epub 2017 Jan 31.

Abstract

Introduction: Surgically induced necrotizing scleritis (SINS) is a rare but serious disorder that can develop many years after strabismus surgery. It is generally treated with high-dose steroids or immunosuppression.

Case report: We describe a patient with Varadi Papp syndrome and congenital fibrosis of the extraocular muscles, who developed surgically induced necrotizing scleritis a month after strabismus surgery and was successfully managed by oral vitamin C and topical N-acetylcysteine 10%.

Discussion: While SINS is conventionally treated with steroids/immunosuppression, a conservative approach may be tried in milder cases. The role of topical N-acetylcysteine in managing this complication needs to be explored.

Keywords: Congenital fibrosis of extraocular muscles; Varadi Papp syndrome; oral vitamin C; surgically induced necrotizing scleritis; topical N-acetylcysteine; treatment.

Publication types

  • Case Reports

MeSH terms

  • Acetylcysteine / therapeutic use*
  • Administration, Topical
  • Ascorbic Acid / administration & dosage
  • Child
  • Fibrosis / complications*
  • Free Radical Scavengers / therapeutic use*
  • Humans
  • Male
  • Oculomotor Muscles / surgery
  • Ophthalmic Solutions
  • Ophthalmologic Surgical Procedures / adverse effects*
  • Ophthalmoplegia / complications*
  • Orofaciodigital Syndromes / complications*
  • Postoperative Complications
  • Scleritis / drug therapy
  • Scleritis / etiology*
  • Strabismus / surgery*

Substances

  • Free Radical Scavengers
  • Ophthalmic Solutions
  • Ascorbic Acid
  • Acetylcysteine

Supplementary concepts

  • Congenital Fibrosis of the Extraocular Muscles
  • Orofaciodigital syndrome 6