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Lett Appl Microbiol. 2017 Apr;64(4):254-260. doi: 10.1111/lam.12722. Epub 2017 Feb 27.

Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402 probiotic regulates growth of commensal Escherichia coli in gut microbiota of familial Mediterranean fever disease subjects.

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Food Safety and Biotechnology Department, Armenian National Agrarian University, Yerevan, Armenia.
International Association for Human and Animals Health Improvement, Yerevan, Armenia.
Yerevan State Medical University, Yerevan, Armenia.
Kyorin University School of Medicine, Tokyo, Japan.
School of Environmental and Biological Sciences, Rutgers State University, New Brunswick, NJ, USA.
Center for Digestive Health, New Jersey Institute for Food, Nutrition and Health, New Brunswick, NJ, USA.


Previously, we reported a positive effect the probiotic formulation, Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402 (Narine strain), had on the blood characteristics of patients with familial Mediterranean fever disease (FMF). The aim of this investigation was to evaluate the effect of the Narine probiotic on growth characteristics in the predominant commensal Escherichia coli isolates from the gut microbiota in FMF-positive study participants. Bacterial growth of 192 prevalent commensal E. coli isolates found in the volunteer participants' guts was evaluated using Verhulst's logistic function. This study showed that the duration of the preparatory growth phase for the E. coli isolates collected from FMF-positive volunteers was significantly shorter, whereas the duration of the logarithmic growth phase was significantly longer (P < 0·03) than that of the isolates collected from healthy participants. The Narine probiotic formulation caused a significant extension (P < 0·001) of the preparatory growth phase in the commensal E. coli isolated from FMF subjects a month after the Narine probiotic administration was terminated. The data suggest that the mathematical model characterizes the growth of commensal E. coli isolates from FMF-positive participants and it can be useful in a decision-making process on the practical use of probiotics during FMF.


This is the first study to demonstrate the effects of Narine, containing the probiotic Lactobacillus acidophilus, on the growth of gut commensal Escherichia coli from study participants with familial Mediterranean fever disease (FMF). Verhulst's logistic function was demonstrated to act as a possible tool for the evaluation and quantification of effects produced by the probiotic formulation in FMF participants.


E. coli ; FMF disease; Verhulst's logistic function; growth preparatory phase; gut microbiota; probiotic

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