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Nat Cell Biol. 2017 Jan 31;19(2):79-81. doi: 10.1038/ncb3460.

CPEB4 links the clock and the UPR to protect the liver.

Author information

1
Department of Pathology, Diabetes Center, and Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, California 94143, USA.

Abstract

Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

PMID:
28139654
PMCID:
PMC5555618
DOI:
10.1038/ncb3460
[Indexed for MEDLINE]
Free PMC Article

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