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Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(12):92-95. doi: 10.17116/jnevro201611612192-95.

[A study of the association between the kynurenine-3-monooxygenase gene and depression].

[Article in Russian; Abstract available in Russian from the publisher]

Author information

1
Research Center of Mental Health, Moscow, Russia.
2
Sechenov First Moscow State Medical University, Moscow, Russia.
3
Geratzy Yerevan State Medical University, Erevan, Armenia.

Abstract

in English, Russian, Russian

AIM:

To study the association between the kynurenine 3-monooxygenase (KMO) and depression.

MATERIAL AND METHODS:

КМО rs2275163 (C/T) and rs1053230 (A /G) polymorphisms were genotyped in patients diagnosed with depression (the main group) and age - and sex-matched healthy people.

RESULTS:

The rs2275163 polymorphism was not associated with depression. There was the association between the rs1053230 polymorphism and depression. The frequency of the low expression genotype GG was higher in the main group compared to controls (р=0.001, ОШ 2.8 (95% ДИ 1.73-4.24). This genotype was earlier reported to be associated with the increased levels of kynurenic acid in patients with bipolar disorders.

CONCLUSION:

The genotype GG can be considered as a risk factor of depression.

PMID:
28139632
DOI:
10.17116/jnevro201611612192-95
[Indexed for MEDLINE]

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