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Fertil Steril. 2017 Mar;107(3):723-730.e3. doi: 10.1016/j.fertnstert.2016.12.022. Epub 2017 Jan 27.

Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial.

Author information

1
Oregon Reproductive Medicine, Portland, Oregon; School of Biosciences, University of Kent, Canterbury, United Kingdom. Electronic address: alison@portlandivf.net.
2
Reprogenetics, Portland, Oregon; School of Biosciences, University of Kent, Canterbury, United Kingdom.
3
Oregon Reproductive Medicine, Portland, Oregon.
4
Koc University School of Medicine, Istanbul, Turkey.
5
Reprogenetics, Livingston, New Jersey.

Abstract

OBJECTIVE:

To compare two commonly used protocols (fresh vs. vitrified) used to transfer euploid blastocysts after IVF with preimplantation genetic screening.

DESIGN:

Randomized controlled trial.

SETTING:

Private assisted reproduction center.

PATIENT(S):

A total of 179 patients undergoing IVF treatment using preimplantation genetic screening.

INTERVENTION(S):

Patients were randomized at the time of hCG administration to either a freeze-all cycle or a fresh day 6 ET during the stimulated cycle.

MAIN OUTCOME MEASURE(S):

Implantation rates (sac/embryo transferred), ongoing pregnancy rates (PRs) (beyond 8 weeks), and live birth rate per ET in the primary transfer cycle.

RESULT(S):

Implantation rate per embryo transferred showed an improvement in the frozen group compared with the fresh group, but not significantly (75% vs. 67%). The ongoing PR (80% vs. 61%) and live birth rates (77% vs. 59%) were significantly higher in the frozen group compared with the fresh group.

CONCLUSION(S):

Either treatment protocol investigated in the present study can be a reasonable option for patients. Freezing all embryos allows for inclusion of all blastocysts in the cohort of embryos available for transfer, which also results in a higher proportion of patients reaching ET. These findings suggest a trend toward favoring the freeze-all option as a preferred transfer strategy when using known euploid embryos.

CLINICAL TRIAL REGISTRATION NUMBER:

NCT02000349.

KEYWORDS:

PGS; aneuploidy; embryos; transfer

[Indexed for MEDLINE]

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