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Future Microbiol. 2017 Feb;12:157-170. doi: 10.2217/fmb-2016-0130.

Roseburia spp.: a marker of health?

Author information

1
INSERM 1241/NUtrition MEtabolism CANcer/CIMIAD, 2 avenue du Professeur Léon Bernard, Rennes, France.
2
CHU Rennes, 2 rue Henri Le Guilloux, 35000 Rennes, France.
3
Université de Rennes 1, 2 avenue du Professeur Léon Bernard, 35043 Rennes, France.

Abstract

The genus Roseburia consists of obligate Gram-positive anaerobic bacteria that are slightly curved, rod-shaped and motile by means of multiple subterminal flagella. It includes five species: Roseburia intestinalis, R. hominis, R. inulinivorans, R. faecis and R. cecicola. Gut Roseburia spp. metabolize dietary components that stimulate their proliferation and metabolic activities. They are part of commensal bacteria producing short-chain fatty acids, especially butyrate, affecting colonic motility, immunity maintenance and anti-inflammatory properties. Modification in Roseburia spp. representation may affect various metabolic pathways and is associated with several diseases (including irritable bowel syndrome, obesity, Type 2 diabetes, nervous system conditions and allergies). Roseburia spp. could also serve as biomarkers for symptomatic pathologies (e.g., gallstone formation) or as probiotics for restoration of beneficial flora.

KEYWORDS:

Roseburia spp.; butyrate; diet; irritable bowel syndrome; microbiota; nervous system

PMID:
28139139
DOI:
10.2217/fmb-2016-0130
[Indexed for MEDLINE]

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