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Biofactors. 2017 May 6;43(3):388-399. doi: 10.1002/biof.1349. Epub 2017 Jan 31.

Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway.

Author information

1
Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German Research Center for Environmental Health, Germany, Member of the German Center for Lung Research (DZL), Munich, Germany.
2
Department of Otolaryngology and Head and Neck Surgery, TUM Medical School, Technical University of Munich, Munich, Germany.
3
Chair and institute of environmental medicine, UNIKA-T, Technical University of Munich and Helmholtz Center Munich, German Research Center for Environmental Health, Augsburg, Germany.
4
CK CARE - Christine Kühne Center for allergy research and education, Davos, Switzerland.
5
Max Zeller Söhne AG, Romanshorn, Switzerland.

Abstract

Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB4 in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll-like-receptor (TLR)-ligands or cytokines, in presence or absence of Ze339. The study uncovers Ze339 modulated changes in pro-inflammatory mediators and decreased neutrophil chemotaxis as well as a reduction of the nuclear translocation and phosphorylation of STAT molecules. Taken together, this study suggests that phyto drug Ze339 specifically targets STAT-signalling pathways in HNECs and has high potential as a broad anti-inflammatory drug that exceeds current indication.

KEYWORDS:

STAT signalling; cytokines; human nasal epithelial cells; microbial patterns; petasin; viral inflammation

PMID:
28139053
DOI:
10.1002/biof.1349
[Indexed for MEDLINE]

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