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Ann Rheum Dis. 2017 Aug;76(8):1357-1364. doi: 10.1136/annrheumdis-2016-210431. Epub 2017 Jan 30.

Long-term dietary quality and risk of developing rheumatoid arthritis in women.

Author information

1
Department of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
2
Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
3
Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
4
Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Abstract

OBJECTIVES:

To evaluate the association between long-term dietary quality, measured by the 2010 Alternative Healthy Eating Index, and risk of rheumatoid arthritis (RA) in women.

METHODS:

We prospectively followed 76 597 women in the Nurses' Health Study aged 30-55 years and 93 392 women in the Nurses' Health Study II aged 25-42 years at baseline and free from RA or other connective tissue diseases. The lifestyle, environmental exposure and anthropometric information were collected at baseline and updated biennially. Cumulative follow-up rates were more than 90% for both cohorts. The primary outcome was RA alone with two subtypes of the disease: seropositive and seronegative RA.

RESULTS:

During 3 678 104 person-years, 1007 RA cases were confirmed. In the multivariable-adjusted model, long-term adherence to healthy eating patterns was marginally associated with reduced RA risk. To assess potential effect modification by age at diagnosis, we stratified by age. Among women aged ≤55 years, better quality diet was associated with lower RA risk (HRQ4 vs Q1: 0.67; 95% CI 0.51 to 0.88; p trend: 0.002), but no significant association was found for women aged >55 years (p interaction: 0.005). When stratifying by serostatus, the inverse association among those aged ≤55 years was strongest for seropositive RA (HRQ4 vs Q1: 0.60; 95% CI 0.42 to 0.86; p trend: 0.003).

CONCLUSIONS:

A healthier diet was associated with a reduced risk of RA occurring at 55 years of age or younger, particularly seropositive RA.

KEYWORDS:

Ant-CCP; Epidemiology; Rheumatoid Arthritis

PMID:
28137914
PMCID:
PMC5556680
DOI:
10.1136/annrheumdis-2016-210431
[Indexed for MEDLINE]
Free PMC Article

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