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Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1707-E1716. doi: 10.1073/pnas.1612136114. Epub 2017 Jan 30.

AlphaB-crystallin regulates remyelination after peripheral nerve injury.

Author information

1
Department of Neuroscience, University of Calgary, Calgary, AB, Canada, T2N 4N1.
2
Hotchkiss Brain Institute, Calgary, AB, Canada, T2N 4N1.
3
Department of Biology, University of Hawai'i at Hilo, Hilo, HI 96720.
4
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, T2N 4N1.
5
Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada, T2N 4N1.
6
Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada, T2N 4N1.
7
Department of Medicine, University of Alberta, Edmonton, AB, Canada, T6G 2B7.
8
Hotchkiss Brain Institute, Calgary, AB, Canada, T2N 4N1; sousman@ucalgary.ca.
9
Department of Cell Biology & Anatomy, University of Calgary, Calgary, AB, Canada, T2N 4N1.

Abstract

AlphaB-crystallin (αBC) is a small heat shock protein that is constitutively expressed by peripheral nervous system (PNS) axons and Schwann cells. To determine what role this crystallin plays after peripheral nerve damage, we found that loss of αBC impaired remyelination, which correlated with a reduced presence of myelinating Schwann cells and increased numbers of nonmyelinating Schwann cells. The heat shock protein also seems to regulate the cross-talk between Schwann cells and axons, because expected changes in neuregulin levels and ErbB2 receptor expression after PNS injury were disrupted in the absence of αBC. Such dysregulations led to defects in conduction velocity and motor and sensory functions that could be rescued with therapeutic application of the heat shock protein in vivo. Altogether, these findings show that αBC plays an important role in regulating Wallerian degeneration and remyelination after PNS injury.

KEYWORDS:

Schwann cells; Wallerian degeneration; alphaB-crystallin; peripheral nerve injury; remyelination

PMID:
28137843
PMCID:
PMC5338501
DOI:
10.1073/pnas.1612136114
[Indexed for MEDLINE]
Free PMC Article

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