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Biochem Biophys Res Commun. 2017 Mar 11;484(3):623-630. doi: 10.1016/j.bbrc.2017.01.152. Epub 2017 Jan 28.

miR-214 down-regulates ARL2 and suppresses growth and invasion of cervical cancer cells.

Author information

1
Precision medicine Center, Tianjin Medical University General Hospital, Tianjin, 300052, PR China.
2
Department of Clinical Laboratory Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, PR China.
3
Precision medicine Center, Tianjin Medical University General Hospital, Tianjin, 300052, PR China. Electronic address: pengruiqing@yeah.net.

Abstract

Increasing evidence has shown that miRNAs are implicated in carcinogenesis and can function as oncogenes or tumor suppressor genes in human cancers. In this study, we confirmed that miR-214 is frequently down-regulated in cervical cancer compared with normal cervical tissues. Ectopic expression of miR-214 suppressed proliferation, migration and invasion of HeLa and C33A cervical cancer cells. Bioinformatics analysis revealed that ADP ribosylation factor like 2 (ARL2) was a potential target of miR-214 and was remarkably up-regulated in cervical cancer. Knockdown of ARL2 markedly inhibited cervical cancer cell proliferation, migration and invasion, similarly to over-expression of miR-214, indicating that ARL2 may function as an oncogene in cervical cancer. In conclusion, our study revealed that miR-214 acts as a tumor suppressor via inhibiting proliferation, migration and invasion of cervical cancer cells through targeting ARL2, and that both miR-214 and ARL2 may serve as prognostic or therapeutic targets for cervical cancer.

KEYWORDS:

ARL2; Cervical cancer; Growth; Invasion; Migration; miR-214

PMID:
28137590
DOI:
10.1016/j.bbrc.2017.01.152
[Indexed for MEDLINE]

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