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J Mol Biol. 2017 Mar 10;429(5):620-632. doi: 10.1016/j.jmb.2017.01.017. Epub 2017 Jan 28.

Regulation of Calcium Homeostasis by ER Redox: A Close-Up of the ER/Mitochondria Connection.

Author information

1
Dulbecco Telethon Institute at IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy.
2
Dulbecco Telethon Institute at IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy. Electronic address: ester.zito@marionegri.it.

Abstract

Calcium signaling plays an important role in cell survival by influencing mitochondria-related processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the main storage compartment for cell calcium (Ca2+; ~60-500μM), and the Ca2+ released by the ER has a prompt effect on the homeostasis of the juxtaposed mitochondria. Recent findings have highlighted a close connection between ER redox and Ca2+ signaling that is mediated by Ca2+-handling proteins. This paper describes the redox-regulated mediators and mechanisms that orchestrate Ca2+ signals from the ER to mitochondria.

KEYWORDS:

IP3R; RyR; SERCA; mitochondria-associated membranes; redox-regulated calcium signaling

PMID:
28137421
DOI:
10.1016/j.jmb.2017.01.017
[Indexed for MEDLINE]

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