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BMC Complement Altern Med. 2017 Jan 31;17(1):80. doi: 10.1186/s12906-017-1606-6.

Effect of the topical application of an ethanol extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice.

Author information

1
Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano, 399-4598, Japan. tkawafb@shinshu-u.ac.jp.
2
Research Center for Fungal & Microbial Dynamism, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano, 399-4598, Japan. tkawafb@shinshu-u.ac.jp.
3
Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano, 399-4598, Japan.
4
Jupon International, 4-31-5 Nishikojiya, Ota-ku, Tokyo, 144-0034, Japan.

Abstract

BACKGROUND:

Quince (Cydonia oblonga Miller) is a deciduous shrub belonging to the Rosaceae family. Quince seed extract has long been used as a cosmetic ingredient for its moisturizing effect. However, little is known about whether quince seed extract has therapeutic effects on keratinocyte-associated skin inflammation.

METHODS:

In the present study, we investigated the effect of the topical application of ethanol extract of quince seeds (QSEtE) on atopic dermatitis (AD) symptoms in NC/Nga mice. The direct effect of QSEtE on keratinocytes was evaluated using the human keratinocyte cell line HaCaT.

RESULTS:

The preliminary application of QSEtE markedly reduced house dust mite allergen-induced skin lesions. The expression of thymus- and activation-regulated chemokine (TARC) in dorsal skin was downregulated. QSEtE directly suppressed the expression and production of TARC in HaCaT cells.

CONCLUSIONS:

The results suggest that the topical application of QSEtE is effective in preventing the onset of and ameliorating the atopic symptoms of keratinocyte-associated skin inflammation by suppressing TARC production in keratinocytes.

KEYWORDS:

Atopic dermatitis; Cydonia oblonga; Keratinocyte; Quince seed; Thymus- and activation-regulated Chemokine

PMID:
28137259
PMCID:
PMC5282862
DOI:
10.1186/s12906-017-1606-6
[Indexed for MEDLINE]
Free PMC Article

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