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Biosci Biotechnol Biochem. 2017 Jun;81(6):1220-1223. doi: 10.1080/09168451.2017.1281729. Epub 2017 Jan 30.

Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2.

Author information

1
a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.

Abstract

We assessed the effect of sulforaphene (SFE) on osteoclast differentiation. SFE significantly decreased the number of RANKL-induced tartrate-resistant acid phosphatase-positive cells and suppressed pre-osteoclast multinucleation. Furthermore, SFE downregulated mRNA expression of DC-STAMP, OC-STAMP, and Atp6v0d2, which encode cell-cell fusion molecules. Our data suggest that SFE attenuates pre-osteoclast multinucleation via suppression of cell-cell fusion.

KEYWORDS:

dendritic cell-specific transmembrane protein (DC-STAMP); isothiocyanate; osteoclast cell fusion; sulforaphene; v-ATPase V0 subunit d2(Atp6v0d2)

PMID:
28136694
DOI:
10.1080/09168451.2017.1281729
[Indexed for MEDLINE]

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