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Small GTPases. 2018 Mar 4;9(1-2):95-106. doi: 10.1080/21541248.2016.1264352. Epub 2017 Jan 31.

New insights into the function of Rab GTPases in the context of exosomal secretion.

Author information

1
a Laboratory of Developmental Erythropoiesis, The Feinstein Institute for Medical Research Hofstra Northwell School of Medicine , Manhasset , NY , USA.
2
b UMR 5235, CNRS, Université Montpellier , cc107, Montpellier , France.

Abstract

In the last two decades, extracellular vesicle-mediated communication between cells has become a major field in cell biology. However, the function of extracellular vesicles is far from clear, especially due to the disparity of released vesicles by cells. Basically, one must consider vesicles budding from the cell plasma membrane (ectosomes) and vesicles released upon fusion of an endosomal multivesicular compartment (exosomes). Moreover, even for exosomes, we report and discuss here the possibility that different routes regulated by specific Rab GTPases might produce exosomes having various biologic functions.

KEYWORDS:

Rab GTPases; communication; disposal; exosomes

PMID:
28135905
PMCID:
PMC5902209
DOI:
10.1080/21541248.2016.1264352
[Indexed for MEDLINE]
Free PMC Article

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