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Sci Rep. 2017 Jan 30;7:41742. doi: 10.1038/srep41742.

Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity.

Author information

1
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
2
Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea.
3
Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
4
Interdisciplinary program in Neuroscience, Seoul National University College of Natural Science, Seoul, Republic of Korea.
5
Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea.

Abstract

Although internet gaming disorder (IGD) and obsessive-compulsive disorder (OCD) represent opposite ends of the impulsivity and compulsivity dimensions, the two disorders share common neurocognitive deficits in response inhibition. However, the similarities and differences in neurophysiological features of altered response inhibition between IGD and OCD have not been investigated sufficiently. In total, 27 patients with IGD, 24 patients with OCD, and 26 healthy control (HC) subjects participated in a Go/NoGo task with electroencephalographic recordings. N2-P3 complexes elicited during Go and NoGo condition were analyzed separately and compared among conditions and groups. NoGo-N2 latency at the central electrode site was delayed in IGD group versus the HC group and correlated positively with the severity of internet game addiction and impulsivity. NoGo-N2 amplitude at the frontal electrode site was smaller in OCD patients than in IGD patients. These findings suggest that prolonged NoGo-N2 latency may serve as a marker of trait impulsivity in IGD and reduced NoGo-N2 amplitude may be a differential neurophysiological feature between OCD from IGD with regard to compulsivity. We report the first differential neurophysiological correlate of the altered response inhibition in IGD and OCD, which may be a candidate biomarker for impulsivity and compulsivity.

PMID:
28134318
PMCID:
PMC5278399
DOI:
10.1038/srep41742
[Indexed for MEDLINE]
Free PMC Article

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