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Proc Natl Acad Sci U S A. 1989 Nov;86(21):8541-4.

Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2'-deoxyguanosine.

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1
Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029.

Abstract

We report that treatment of 2.2.15, a human hepatoblastoma-derived cell line in which hepatitis B virus is actively replicating, with the carbocyclic analogue of 2'-deoxyguanosine [Shealy, Y. F., O'Dell, C. A., Shannon, W. M. & Arnett, G. (1984) J. Med. Chem. 27, 1416-1421] resulted in the nearly complete cessation of viral replication, as monitored by the absence of both intracellular episomal and secreted viral DNAs and by the absence of viral DNA polymerase activity. The drug was nontoxic in concentrations up to 200 times the minimum effective inhibitory concentration.

PMID:
2813411
PMCID:
PMC298318
[Indexed for MEDLINE]
Free PMC Article
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