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Immunol Rev. 2017 Jan;275(1):161-182. doi: 10.1111/imr.12481.

Native-like Env trimers as a platform for HIV-1 vaccine design.

Author information

1
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.
2
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Abstract

We describe the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trimers that mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies. The goal of trimer development programs is to induce broadly neutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains. Among the topics we address are the designs of various constructs; how native-like trimers can be produced and purified; the properties of such trimers in vitro and their immunogenicity in various animals; and the immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies. In summary, native-like trimers are a now a platform for structure- and immunology-based design improvements that could eventually yield immunogens of practical value for solving the long-standing HIV-1 vaccine problem.

KEYWORDS:

Env trimers; HIV-1 vaccines; neutralizing antibodies

PMID:
28133806
PMCID:
PMC5299501
DOI:
10.1111/imr.12481
[Indexed for MEDLINE]
Free PMC Article

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