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Evid Based Complement Alternat Med. 2017;2017:1691568. doi: 10.1155/2017/1691568. Epub 2017 Jan 4.

Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients.

Author information

1
Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria; Laboratoire de Physiologie Animale, Département de Biologie Animale, Faculté des Sciences de la Nature et de la Vie, Université Constantine 1, 25000 Constantine, Algeria; Clinic of Urology-Nephrology and Kidney Transplant Daksi, Constantine, Algeria.
2
CNC-Center for Neuroscience and Cellular Biology, UC-Biotech Building, Biocant Park, University of Coimbra, Coimbra, Portugal.
3
Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria; Laboratoire de Physiologie Animale, Département de Biologie Animale, Faculté des Sciences de la Nature et de la Vie, Université Constantine 1, 25000 Constantine, Algeria.
4
Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Constantine 1, 25000 Constantine, Algeria.
5
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
6
Clinic of Urology-Nephrology and Kidney Transplant Daksi, Constantine, Algeria.

Abstract

Green tea (GT) has been studied for its effects as antioxidant and cancer-preventive agent. Epidemiological studies showed that GT consumption decreases the risk for prostate cancer (PC). To investigate whether erythrocyte oxidative stress (OS) is associated with PC and whether daily consumption of GT improves the oxidative phenotype, we performed a study in a group of Algerian PC patients, preceded by an in vitro study to characterize composition and antioxidant/antiproliferative activities of the GT used. This contained a high content of phenolic and flavonoid compounds, demonstrating in vitro antioxidant activity and significant antiproliferative effect on human prostate cancer PC-3 cell line. Seventy PC patients and 120 age-matched healthy subjects participated in the study, with glutathione (GSH), malondialdehyde (MDA), and catalase activity evaluated before and after GT consumption. The results showed a reduced GSH and catalase activity and a high level of MDA in erythrocytes from PC patients. The consumption of 2-3 cups per day of GT during 6 months significantly increased GSH concentration and catalase activity and decreased MDA concentration. In conclusion, GT significantly decreased OS in Algerian PC patients. Regular consumption of GT for a long period may prevent men from developing PC or at least delay its progression.

Conflict of interest statement

The authors declare that they have no competing interests.

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