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Neuron. 2017 Feb 8;93(3):691-704.e5. doi: 10.1016/j.neuron.2016.12.011. Epub 2017 Jan 26.

Physiological Properties and Behavioral Correlates of Hippocampal Granule Cells and Mossy Cells.

Author information

1
Neuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, USA.
2
Neuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, USA; Department of Neurology, Langone Medical Center, New York University, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: gyorgy.buzsaki@nyumc.org.

Abstract

The hippocampal dentate gyrus is often viewed as a segregator of upstream information. Physiological support for such function has been hampered by a lack of well-defined characteristics that can identify granule cells and mossy cells. We developed an electrophysiology-based classification of dentate granule cells and mossy cells in mice that we validated by optogenetic tagging of mossy cells. Granule cells exhibited sparse firing, had a single place field, and showed only modest changes when the mouse was tested in different mazes in the same room. In contrast, mossy cells were more active, had multiple place fields and showed stronger remapping of place fields under the same conditions. Although the granule cell-mossy cell synapse was strong and facilitating, mossy cells rarely "inherited" place fields from single granule cells. Our findings suggest that the granule cells and mossy cells could be modulated separately and their joint action may be critical for pattern separation.

KEYWORDS:

Dentate gyrus; facilitating synapse; gamma; granule cell; monosynaptic connections; mossy cell; pattern separation; place cells; spatial behavior; theta

PMID:
28132824
PMCID:
PMC5293146
DOI:
10.1016/j.neuron.2016.12.011
[Indexed for MEDLINE]
Free PMC Article

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