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Postepy Biochem. 2016;62(4):459-471.

[The key role of AMP-activated protein kinase (AMPK) in aging process].

[Article in Polish; Abstract available in Polish from the publisher]

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Department of Metabolic Regulation, Biochemistry Institute, Faculty of Biology, University of Warsaw, 1 Miecznikowa St., 02-096 Warszawa, Poland.


in English, Polish

Aging is one of the most extensively studied biological process and yet still some of its aspects remain elusive. It appears that AMP - activated protein kinase (AMPK) plays an important role in many processes of aging, but this fact is often neglected in the studies on aging. This work summarizes the information about AMPK participation in the aging process. AMPK participation in the regulation of aging was indicated in the mechanisms dependent on: caloric restriction, mTOR, p53, sirtuins, autophagy, inflammation and the effects caused by polyphenols.


AMPK; aging; longevity

[Indexed for MEDLINE]
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