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Vaccine. 2017 Feb 22;35(8):1104-1109. doi: 10.1016/j.vaccine.2017.01.018. Epub 2017 Jan 25.

Improving the selection and development of influenza vaccine viruses - Report of a WHO informal consultation on improving influenza vaccine virus selection, Hong Kong SAR, China, 18-20 November 2015.

Author information

  • 1Interflu Pty Ltd, Victoria, Australia. Electronic address: interflu@bigpond.net.au.
  • 2Victorian Infectious Diseases Reference Laboratory (VIDRL), Melbourne, Australia. Electronic address: Ian.Barr@influenzacentre.org.
  • 3Centers for Disease Control and Prevention (CDC), Atlanta, USA. Electronic address: njc1@cdc.gov.
  • 4Biomedical Advanced Research and Development Authority (BARDA), ASPR, US Department of Health and Human Services, Washington DC, USA. Electronic address: Ruben.Donis@hhs.gov.
  • 5Global Influenza Programme, World Health Organization (WHO), Geneva, Switzerland. Electronic address: hirves@who.int.
  • 6Centers for Disease Control and Prevention (CDC), Atlanta, USA. Electronic address: dbj0@cdc.gov.
  • 7Centers for Disease Control and Prevention (CDC), Atlanta, USA. Electronic address: jmk9@cdc.gov.
  • 8The Francis Crick Institute, London, UK. Electronic address: John.McCauley@crick.ac.uk.
  • 9Instituto Oswaldo Cruz, Rio de Janeiro, Brazil. Electronic address: fcm@ioc.fiocruz.br.
  • 10National Institute of Infectious Diseases, Tokyo, Japan. Electronic address: todagiri@nih.go.jp.
  • 11The Hong Kong Polytechnic University, Hong Kong Special Administrative Region. Electronic address: johntam64@yahoo.com.
  • 12Freelance writer and editor, Stanley, UK. Electronic address: waddell.t@btinternet.com.
  • 13St Jude Childrens Research Hospital, Memphis, USA. Electronic address: richard.webby@stjude.org.
  • 14Global Influenza Programme, World Health Organization (WHO), Geneva, Switzerland. Electronic address: thedi.ziegler@utu.fi.
  • 15Global Influenza Programme, World Health Organization (WHO), Geneva, Switzerland. Electronic address: zhangw@who.int.

Abstract

Since 2010 the WHO has held a series of informal consultations to explore ways of improving the currently highly complex and time-pressured influenza vaccine virus selection and development process. In November 2015 experts from around the world met to review the current status of efforts in this field. Discussion topics included strengthening influenza surveillance activities to increase the availability of candidate vaccine viruses and improve the extent, timeliness and quality of surveillance data. Consideration was also given to the development and potential application of newer laboratory assays to better characterize candidate vaccine viruses, the potential importance of antibodies directed against influenza virus neuraminidase, and the role of vaccine effectiveness studies. Advances in next generation sequencing and whole genome sequencing of influenza viruses were also discussed, along with associated developments in synthetic genomics technologies, evolutionary analysis and predictive mathematical modelling. Discussions were also held on the late emergence of an antigenic variant influenza A(H3N2) virus in mid-2014 that could not be incorporated in time into the 2014-15 northern hemisphere vaccine. There was broad recognition that given the current highly constrained influenza vaccine development and production timeline it would remain impossible to incorporate any variant virus which emerged significantly long after the relevant WHO biannual influenza vaccine composition meetings. Discussions were also held on the development of pandemic and broadly protective vaccines, and on associated regulatory and manufacturing requirements and constraints. With increasing awareness of the health and economic burdens caused by seasonal influenza, the ever-present threat posed by zoonotic influenza viruses, and the significant impact of the 2014-15 northern hemisphere seasonal influenza vaccine mismatch, this consultation provided a very timely opportunity to share developments and exchange views. In all areas, a renewed and strengthened emphasis was placed on developing concrete and measurable actions and identifying the key stakeholders responsible for their implementation.

KEYWORDS:

Antigenic drift; Influenza vaccines; Pandemic influenza; Surveillance

PMID:
28131392
DOI:
10.1016/j.vaccine.2017.01.018
[PubMed - in process]
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