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J Biomed Mater Res A. 2017 May;105(5):1281-1292. doi: 10.1002/jbm.a.36013. Epub 2017 Feb 14.

Effects of aging upon the host response to implants.

Author information

1
McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, Pennsylvania, 15219.
2
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.
3
Department of Pathology, University of Pittsburgh School of Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, Pennsylvania, 15261.
4
Department of Chemical Engineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, Pennsylvania, 15260.
5
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, University of Pittsburgh, 300 Halket Street, Pittsburgh, Pennsylvania, 15213.

Abstract

Macrophage polarization during the host response is now a well-accepted predictor of outcomes following material implantation. Immunosenescence, dysregulation of macrophage function, and delayed resolution of immune responses in aged individuals have all been demonstrated, suggesting that host responses to materials in aged individuals should differ from those in younger individuals. However, few studies examining the effects of aging upon the host response have been performed. The present work sought to elucidate the impacts of aging upon the host response to polypropylene mesh implanted into 8-week-old and 18-month-old mice. The results showed that there are significant differences in macrophage surface marker expression, migration, and polarization during the early host macrophage response and delayed resolution of the host response in 18-month-old versus 8-week-old mice. These differences could not be attributed to cell-intrinsic defects alone, suggesting that the host macrophage response to implants is likely also dictated to a significant degree by the local tissue microenvironment. These results raise important questions about the design and testing of materials and devices often intended to treat aged individuals and suggest that an improved understanding of patient- and context-dependent macrophage responses has the potential to improve outcomes in aged individuals.

KEYWORDS:

aging; host response; implant; macrophage; polarization

PMID:
28130823
PMCID:
PMC5963506
DOI:
10.1002/jbm.a.36013
[Indexed for MEDLINE]
Free PMC Article

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