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Mol Diagn Ther. 2017 Jun;21(3):285-294. doi: 10.1007/s40291-016-0253-9.

MicroRNA-29: A Crucial Player in Fibrotic Disease.

Deng Z1, He Y1,2, Yang X1, Shi H1, Shi A3, Lu L4,5, He L6.

Author information

1
Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.
2
Department of Plastic Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
3
Department of Biochemistry, Wheaton College, Norton, Massachusetts, USA.
4
Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. minimillet@hotmail.com.
5
Department of Physiology, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China. minimillet@hotmail.com.
6
Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. heli2661@163.com.

Abstract

Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases.

PMID:
28130757
DOI:
10.1007/s40291-016-0253-9
[Indexed for MEDLINE]

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