Format

Send to

Choose Destination
Bioorg Chem. 2017 Apr;71:67-73. doi: 10.1016/j.bioorg.2017.01.012. Epub 2017 Jan 19.

Renoprotective chemical constituents from an edible mushroom, Pleurotus cornucopiae in cisplatin-induced nephrotoxicity.

Author information

1
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
2
Department of Food and Nutrition, Gachon University, Seongnam 13120, Republic of Korea.
3
Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseoung 369-873, Republic of Korea.
4
College of Pharmacy, CHA University, Pocheon 487-010, Republic of Korea.
5
College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
6
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. Electronic address: khkim83@skku.edu.

Abstract

Pleurotus cornucopiae (Pleurotaceae) is an edible and medicinal mushroom widely distributed in Korea, China, and Japan. The MeOH extract of the fruiting bodies of P. cornucopiae showed renoprotective effects against cisplatin-induced kidney cell damage. Chemical investigation of the MeOH extract led to the isolation and identification of 12 compounds including noransine (1), uridine (2), uracil (3), (3β, 5α, 6β, 22E, 24S) -ergosta-7, 22-diene-3, 5, 6, 9-tetrol (4), (22E,24S)-ergosta-7,22-diene-3β,5α,6β-triol (5), (22E,24R)-ergosta-8(14),22-diene-3β,5α,6β,7α-tetrol (6), cerebroside B (7), (2R) -N- [(1S, 2R, 3E, 7E) -1- [(β-d-glucopyranosyloxy) methyl] -2-hydroxy-8-methyl-3, 7-heptadecadien-1-yl] -2-hydroxy-heptadecanamide (8), cerebroside D (9), nicotinamide (10), 1,2-bis(hydroxymethyl)-4,5-dimethoxybenzene (11), and benzoic acid (12). Among them, compounds 1 and 11 were isolated as naturally occurring products for the first time, though they were reported as synthetic products in previous papers. All of the compounds (except 8 and 11) abrogated cisplatin-induced LLC-PK1 cell damage in a dose-dependent manner. Of special note, compounds 2, 5, 6, and 12 ameliorated cisplatin-induced nephrotoxicity to 80% of the control value at 10μM. The protective effects of compounds 2, 5, 6, and 12 were mediated via the deactivation of JNK-caspase 3 apoptotic cascade. This study is the first to demonstrate that the chemical constituents of P. cornucopiae display renoprotective effects against anticancer drug-induced damage in kidney cells.

KEYWORDS:

MAPKs; Mushroom; Nephrotoxicity; Pleurotaceae; Pleurotus cornucopiae

PMID:
28129885
DOI:
10.1016/j.bioorg.2017.01.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center