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Methods Cell Biol. 2017;138:651-679. doi: 10.1016/bs.mcb.2016.10.004. Epub 2016 Dec 29.

Chemical screening in zebrafish for novel biological and therapeutic discovery.

Author information

1
Stem Cell Program and Division of Hematology and Oncology, Childrens' Hospital Boston, Dana-Farber Cancer Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, United States.

Abstract

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.

KEYWORDS:

Chemical; Chemoinformatic; Hit; Libraries; Phenotype; Screen; Zebrafish

PMID:
28129862
PMCID:
PMC5535795
DOI:
10.1016/bs.mcb.2016.10.004
[Indexed for MEDLINE]
Free PMC Article

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