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Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2497-2502. doi: 10.1002/anie.201609180. Epub 2017 Jan 27.

Functional Isoeugenol-Modified Nanogel Coatings for the Design of Biointerfaces.

Author information

1
Funktionelle und interaktive Polymere, DWI-Leibniz Institut für Interaktive Materialien, Forckenbeckstrasse 50, 52056, Aachen, Germany.
2
Lehr- und Forschungsgebiet Orale Mikrobiologie und Immunologie der Klinik für Zahnerhaltung, ZPP, Uniklinik, RWTH Aachen, Germany.
3
Institut für Pathologie und Helmholtz Institut für Biomedizinische Technologien-Zell- und Molekularbiologie an Grenzflächen, Uniklinik, RWTH Aachen, Germany.

Abstract

A new route for the synthesis of functional aqueous nanogels decorated with a controlled amount of surface-drafted isoeugenol molecules has been developed. Obtained nanogels exhibit two key functions: a) antibacterial activity against different oral pathogens and b) cell-adhesive and -growth-promoting properties. Functional nanogels can be potentially used as building blocks in the design of bioactive coatings on various implants preventing infections and accelerating tissue regeneration.

KEYWORDS:

antibacterial properties; cell adhesion; gels; isoeugenol; oral pathogens

PMID:
28128895
DOI:
10.1002/anie.201609180
[Indexed for MEDLINE]

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