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Acta Paediatr. 2017 May;106(5):755-762. doi: 10.1111/apa.13757. Epub 2017 Feb 28.

Policy of feeding very preterm infants with their mother's own fresh expressed milk was associated with a reduced risk of bronchopulmonary dysplasia.

Author information

1
Department of Neonatology, Children Hospital, University Hospital, Toulouse, France.
2
U.1027, INSERM, Toulouse, France.
3
Paul Sabatier University, Toulouse, France.
4
Department of Woman, Mother and Child, University Hospital, Brest, France.
5
Department of Neonatal Medicine, University Hospital, Nantes, France.
6
Clinical Epidemiology Unit, CHU Purpan, Toulouse, France.

Abstract

AIM:

Since 2005, the French Food Safety Agency has recommended that very preterm or low-birthweight babies should be fed with pasteurised, expressed breastmilk, and feeding policies on this vary widely in French neonatal units. We investigated the differences between using a mother's expressed milk, in fresh or pasteurised forms, for very preterm infants.

METHODS:

This observational multicentre study analysed data on 926 very preterm infants: 636 from neonatal units who used the mother's own fresh milk and 290 who used the mother's milk after pasteurisation. We analysed necrotising enterocolitis, bronchopulmonary dysplasia, in-hospital mortality, late-onset sepsis, weight gain, length of hospital stay, the duration of parenteral nutrition and the duration of enteral feeding with a nasogastric tube. Multivariate analyses were conducted to assess the impact of maternal milk policies.

RESULTS:

After adjustment, there was a reduced risk of bronchopulmonary dysplasia in the fresh milk group with an odds ratio of 0.40 and 95% confidence interval of 0.27-0.67 (p < 0.001). No other statistically significant differences were observed.

CONCLUSION:

Feeding very preterm infants with their mother's expressed fresh milk was associated with a reduced risk of bronchopulmonary dysplasia, and further investigations are needed to evaluate the clinical impact of this practice.

KEYWORDS:

Bronchopulmonary dysplasia; Fresh breastmilk; Neonatal intensive care unit; Pasteurisation; Very preterm infants

PMID:
28128874
DOI:
10.1111/apa.13757
[Indexed for MEDLINE]

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