Format

Send to

Choose Destination
J Obstet Gynaecol Res. 2017 Mar;43(3):436-446. doi: 10.1111/jog.13250. Epub 2017 Jan 27.

Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review.

Author information

1
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
2
Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
3
Colégio Técnico (COLTEC), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Abstract

Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic alterations, such as hyperandrogenism, obesity, menstrual irregularities, insulin resistance, and polycystic ovaries. The etiology remains unclear, but several genetic and environmental factors have been correlated with manifestations of this syndrome. Vitamin D plays important roles in metabolic pathways affected by PCOS, including calcium homeostasis, the insulin pathway, and sex hormone synthesis. Vitamin D concentration has been related with the severity of this disorder, and vitamin D receptor polymorphisms have been shown in some studies to have an association with some of the patterns presented by PCOS. The objective of this study is to provide an up-to-date review about vitamin D receptor polymorphisms and their association with PCOS.

KEYWORDS:

hyperandrogenism; insulin resistance; obesity; polycystic ovary syndrome; polymorphisms; vitamin D receptor

PMID:
28127831
DOI:
10.1111/jog.13250
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center