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Sci Rep. 2017 Jan 31;7(1):5. doi: 10.1038/s41598-017-00037-7.

Lipidome determinants of maximal lifespan in mammals.

Author information

1
CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China. kasia.bozek@oist.jp.
2
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany. kasia.bozek@oist.jp.
3
Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, 904-0495, Japan. kasia.bozek@oist.jp.
4
Skoltech Center for Computational and Systems Biology, Skolkovo Institute for Science and Technology, Novaya st. 100, Skolkovo, 143025, Russia.
5
Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoy Karetny per. 19/1, Moscow, 127051, Russia.
6
Max-Delbrück Center for Molecular Medicine, Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa.
7
Max-Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13092, Berlin, Germany.
8
Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa.
9
University of Rochester, 434 Hutchison Hall, Rochester, NY, 14627-0211, USA.
10
SILABE, Primatology Center, University Louis Pasteur, Strasbourg, 4 Rue Blaise Pascal, 67070, France.
11
UMR 7179/CNRS-MNHN, 1 avenue du Petit Chateu, 91800, Brunoy, France.
12
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Dong Lu, Kunming, Yunnan, 650223, China.
13
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany.
14
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Germany.
15
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Germany. giavalisco@mpimp-golm.mpg.de.
16
CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China. khaitovich@eva.mpg.de.
17
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany. khaitovich@eva.mpg.de.
18
Skoltech Center for Computational and Systems Biology, Skolkovo Institute for Science and Technology, Novaya st. 100, Skolkovo, 143025, Russia. khaitovich@eva.mpg.de.

Abstract

Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.

PMID:
28127055
PMCID:
PMC5428381
DOI:
10.1038/s41598-017-00037-7
[Indexed for MEDLINE]
Free PMC Article

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